Journal: BMC Complementary Medicine and Therapies

Article Title: Cytotoxicity, acute and sub-chronic toxicities of the fruit extract of Tetrapleura tetraptera (Schumm. & Thonn.) Taub. (Fabaceae)

doi: 10.1186/s12906-022-03659-1

Figure Lengend Snippet: Chemical structures of compounds 1 to 9 isolated from TTF extract. 1: (3 R , 4S)-3,4-dimethyloxetan-2-one; 2: luteolin, 3: stigmasterol; 4; 3- O -[6’- O -undecanoyl- β - D -glucopyranosyl]stigmasterol; 5: oleanan-12-en-3- β - O - D -glucopyranoside; 6: 3- O - β - D -glucopyranosyl-(1 → 6)- β - D -glucopyranosylurs-12-en-28-oic acid; 7: 3- O - β - D -glucopyranosyl-(1 → 3)- β - D -glucopyranosyl-27-hydroxyolean-12-ene-28-oic acid; 8: methyl- O - β - D -glucopyranoside; 9: β - D -fructofuranosyl-(2 → 1)- β - D -glucopyranoside

Article Snippet: Furthermore, the methanol crude extract of TTF fruits and four of its isolated constituents had antiproliferative activity towards drug-susceptible and multidrug-resistant cancer lines, with IC 50 values for the crude extract and the most active compound (olean-12-en-3- β-O - D -glucopyranoside) ranging from 10.27 μg/mL (in CCRF-CEM leukemia cells) and 23.61 μg/mL (against HCT116 p53 −/− colon adenocarcinoma cells) and from 4.76 μM (against CCRF-CEM cells) to 12.92 μM (against HepG2 hepatocarcinoma cells) [ ].

Techniques: Isolation